Annabelle Rodriguez, M.D.
Adjunct Associate Professor of Medicine
The Johns Hopkins University
School of Medicine

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Dr. Rodriguez's team has been a pioneer in identifying patients who have deficiency of the HDL receptor, also called scavenger receptor class B type I or SR-BI. Deficiency of this receptor is associated with higher fractions of the good, HDL, cholesterol fraction, but surprisingly this is associated with risk for hardening of the arteries (atherosclerosis). Yes, patients can have high levels of the good cholesterol but still have heart disease. Also, surprisingly, some women with deficiency of the SR-BI receptor can have problems with fertility. This is because this SR-BI receptor is important in the production of the female hormone, progesterone, which is vital to fertility. The Johns Hopkins DNA Diagnostic Lab now offers a genetic test for deficiency of the SR-BI receptor, You can reach the DNA Lab with this link.

Dr. Rodriguez's team has been successful in competing for funding from prestigious sources such as the National Institutes of Health and the Burroughs Wellcome Fund. Dr. Rodriguez was recently named editor of a new textbook, Translational Cardiometabolic Genomic Medicine. The goal for this new textbook is to bridge the intersection of basic science research in the area of cholesterol metabolism, genomics and personalized medicine.


Dr. Annabelle Rodriguez, M.D.

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