Annabelle Rodriguez, M.D.
Adjunct Associate Professor of Medicine
The Johns Hopkins University
School of Medicine

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RESEARCH ARTICLES:


Improving Inpatient Glycemic Control: Expert Insights CME
Annabelle Rodriguez, Guillermo Umpierrez, Jane Jeffrie Seley, - Medscape Education Released: 09/14/2011 - The goal of this activity is to provide healthcare clinicians with expert perspectives on current best evidence and treatment guidelines with a focus on identifying and achieving specific glycemic targets using evidence-based means in hospitalized patients who have hyperglycemia with or without diabetes. This article is a CME-certified activity.


Clinical impact of scavenger receptor class B type I gene polymorphisms on human female fertility
Melissa Yates, Antonina Kolmakova, Yulian Zhao and Annabelle Rodriguez - Oxford Journals Human Reproduction - The goal of this study was to evaluate the association of SCARB1 single nucleotide polymorphisms (SNPs) and fertility outcomes in women undergoing IVF.


Chronic intermittent hypoxia induces atherosclerosis
S Bevans, PL Smith, A Rodriguez… - American journal of …, 2007 - 171.66.122.149 Measurements and Main Results: Nine of 10 mice simultaneously exposed to CIH and high-cholesterol diet developed atherosclerotic lesions in the aortic origin and descending aorta. In contrast, atherosclerosis was not observed in mice exposed to intermittent air and a high-cholesterol diet or in mice ...


Intermittent hypoxia induces hyperlipidemia in lean mice
PL Smith, RL Marino, A Rodriguez… - Circulation …, 2005 - Am Heart Assoc Kluwer Health, 351 West Camden Street, Baltimore, MD 21202-2436. Phone: 410-528-4050. Permissions: Permissions & Rights Desk, Lippincott Williams & Wilkins, a division of Wolters ... Intermittent Hypoxia Induces Hyperlipidemia in Lean Mice


Aging, androgens, and the metabolic syndrome in a longitudinal study of aging
A Rodriguez, DC Muller, EJ Metter… - Journal of Clinical …, 2007 - Endocrine Soc Methods and Results: Study participants were Caucasian community-dwelling adult men in the Baltimore Longitudinal Study of Aging, who underwent a fasting 2-h oral glucose tolerance test and had serum concentrations of total testosterone (T), dehydroepiandrosterone sulfate, ...


Influence of high density lipoprotein on esterified cholesterol stores in macrophages and hepatoma cells
DW Bernard, A Rodriguez… - … , and Vascular Biology, 1990 - Am Heart Assoc 1524-4636 Copyright © 1990 American Heart Association. All rights reserved. Print ISSN: 1079-5642. Online ISSN: 7272 Greenville Avenue, Dallas, TX 72514 Arteriosclerosis, Thrombosis, and Vascular Biology is published by the American Heart Association.


Novel Effects of the Acyl-Coenzyme A: Cholesterol Acyltransferase Inhibitor 58-035 on Foam Cell Development in Primary Human Monocyte–Derived Macrophages
A Rodriguez, PS Bachorik… - … , thrombosis, and vascular …, 1999 - Am Heart Assoc Abstract—We examined the effect of acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitors on intracellular cholesterol stores in primary human monocyte–derived macrophages (HMMs) during foam cell formation. HMMs were exposed to acetylated low density ...


Efficacy and safety of statin monotherapy in older adults: a meta-analysis
E Guallar, A Rodriguez - The Journals …, 2007 - biomedgerontology.oxfordjournals. … Background. Statin therapy significantly reduces cardiovascular events. Older patients, however, are less likely to be prescribed statins than younger patients due to concern over lack of indication, lower predictive value of cholesterol levels, and increased risk of adverse ...


Sterol carrier protein 2 gene transfer changes lipid metabolism and enterohepatic sterol circulation in mice
S Zanlungo*, L Amigo*, H Mendoza*, JF Miquel*… - Gastroenterology, 2000 - Elsevier ... Silvana Zanlungo* a , Ludwig Amigo* a , Hegaly Mendoza* a , Juan Francisco Miquel* a , Carlos V??o† a , Jane M. Glick§ a , Annabelle Rodr??guez a , Karen Kozarsky¶ a , Verónica Quiñones* a , Attilio Rigotti* a and Flavio Nervi* a. ...


Contribution of impaired glucose tolerance in subjects with the metabolic syndrome: Baltimore Longitudinal Study of Aging
A Rodriguez, DC Muller, M Engelhardt… - Metabolism, 2005 - Elsevier Study participants were white adults in the Baltimore Longitudinal Study of Aging who underwent a fasting 2-hour OGTT. In men between the ages of 20 to 39, 40 to 59, 60 to 79, and 80 to 95 years, the prevalence of the MS by Adult Treatment Panel (ATP) III criteria (which ...


Anti-atherogenic effects of the acyl-CoA: cholesterol acyltransferase inhibitor, avasimibe (CI-1011), in cultured primary human macrophages
A Rodriguez… - Atherosclerosis, 2002 - Elsevier Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors have been shown to reduce atherosclerotic lesions in animals; however, the mechanism(s) for this effect remains unclear. Therefore, we used cultured primary human monocyte-derived macrophages (HMMs) to examine the ...


cAMP stimulates cholesteryl ester clearance to high density lipoproteins in J7774 macrophages.
DW Bernard, A Rodriguez, GH Rothblat… - Journal of Biological …, 1991 - ASBMB The regulation by cAMP of cholesteryl ester hydrol- ysis and net depletion of cellular cholesteryl ester (cho- lesteryl ester clearance) in 5774 murine macrophages was explored. Using Sandoz 58035 to selectively in- hibit acyl CoA:cholesterol acyltransferase, we showed that the ...


Insulin-related knowledge among health care professionals in internal medicine
L Bronich-Hall, A Rodriguez - Diabetes …, 2007 - Am Diabetes Assoc Results. The percentage of knowledge-based questions answered correctly was low: 51% for faculty, 59% for house staff, and 47% for nurses. Scores on questions testing knowledge of insulin nomenclature and characteristics were similar to scores on those addressing inpatient ...


Association of lower plasma estradiol levels and low expression of scavenger receptor class B, type I in infertile women
J King, Y Zhao, J Garcia, A Rodriguez - Fertility and sterility, 2006 - Elsevier The expression of SR-BI RNA and protein were positively correlated. The prevalence of low SR-BI RNA expression (defined as below 25th percentile) was 26%, whereas the prevalence of high SR-BI expression (defined as above 75th percentile) was 24%. Expression of ...


Potential problems in the use of commercial preparations of radiolabeled cholesterol
FH Mahlberg, A Rodriguez-Oquendo, DW Bernard… - Atherosclerosis, 1990 - Elsevier Through a series of biological and analytical procedures, we demonstrate that a compound purchased from a commercial supplier as [7- 3 H]cholesterol was not cholesterol. In mouse peritoneal macrophages, this compound was metabolized differently than other radiolabeled ...


Update on the role of acyl-CoA: cholesterol acyltransferase inhibitors in atherosclerosis
…, R Fishelevich, A Rodriguez… - Expert Opinion on …, 2001 - informahealthcare.com Cardiovascular disease is one of the leading causes of mortality and morbidity in industrialised nations. Hypercholesterolaemia is one of a number of risk factors identified that influences the development and progression of atherosclerosis. While drugs such as HMGCoA ...


Association of cholesterol subfractions and carotid lipid core measured by MRI
MY Desai, A Rodriguez, BA Wasserman… - … and Vascular Biology, 2005 - Am Heart Assoc MRI can noninvasively visualize arterial wall remodelling and atherosclerotic plaque components (lipid core, fibrous cap, and calcium). 8,9 However, in vivo relationships between plaque components and cholesterol subfractions have not been demonstrated in humans. We examined in ...


Scavenger receptor class B type I protein as an independent predictor of high-density lipoprotein cholesterol levels in subjects with hyperalphalipoproteinemia
B Asztalos, TI Pollin, A Rodriguez - Journal of Clinical …, 2009 - Endocrine Soc Design: This was a prospective study of adults with hyperalphalipoproteinemia. Fasting blood was obtained for lipid and lipoprotein measurement, genomic DNA, and monocyte-derived macrophages. SR-BI protein levels were measured by Western blots, and SR-BI activity ...


Expression of scavenger receptor-BI and low-density lipoprotein receptor and differential use of lipoproteins to support early steroidogenesis in luteinizing macaque …
M Puttabyatappa, E Greason, A Rodriguez… - Endocrinology, 2009 - Endocrine Soc An ovulatory hCG stimulus to rhesus macaques undergoing controlled ovarian stimulation protocols results in a rapid and sustained increase in progesterone synthesis. The use of lipoproteins as a substrate for progesterone synthesis remains unclear, and the expression of lipoprotein ...


Scavenger receptor class B type I protein as an independent predictor of HDL cholesterol levels in subjects with hyperalphalipoproteinemia
B Asztalos, TI Pollin, A Rodriguez - Journal of Clinical …, 2009 - Endocrine Soc Page 1. J. Clin. Endocrinol. Metab. published online Jan 21, 2009; , doi: 10.1210/jc.2008-1223 Michael West, Erin Greason, Antonina Kolmakova, Anisa Jahangiri, Bela Asztalos, Toni I. Pollin and Annabelle Rodriguez HYPERALPHALIPOPROTEINEMIA ...


Cell density can affect cholesteryl ester accumulation in the human THP-1 macrophage.
A Rodriguez, SD Kafonek, A Georgopoulos… - Journal of lipid …, 1994 - ASBMB Department of Medicine* and Department of Pediatrics and Laboratory Medicine, t Johns Hopkins University School of Medicine, Baltimore, MD 21287 ... Abstract Esterified cholesterol (EC) accumulation was in- duced in THP-1 macrophages after exposure to acetylated LDL (acLDL), and the ...


Low density lipoprotein (LDL) inhibits histamine release from human mast cells
…, TJ Post, P O'Donnell, A Rodriguez… - Biochemical and …, 1987 - Elsevier We examined the effect of low density lipoprotein (LDL) on histamine release from purified human lung mast cells. LDL inhibited anti-IgE- induced histamine release in a dose-dependent manner, with 100?g/ml LDL-protein inhibiting histamine release by 83±8% (mean±SEM); ...


Potential therapeutic agents that raise high-density lipoprotein cholesterol levels
A Rodriguez… - Expert Opinion on Therapeutic …, 2003 - informahealthcare.com Cardiovascular disease remains one of the leading causes of death in western- ised societies. A number of risk factors have been identified that accelerate the risk for cardiovascular disease (CVD), including family history for prema- ture disease (first degree male relative ...


Association of Scavenger Receptor Class B Type I Polymorphisms with Subclinical Atherosclerosis: The Multi-Ethnic Study of Atherosclerosis
…, DM Herrington, A Rodriguez - Circulation: …, 2009 - Am Heart Assoc World Wide Web at: The online version of this article, along with updated information and services, is located on the ... Association of Scavenger Receptor Class B Type I Polymorphisms with ... Subclinical Atherosclerosis: The Multi-Ethnic Study of Atherosclerosis


Nitric oxide metabolite production in the human preimplantation embryo and successful blastocyst formation
…, Y Zhao, K Thrift, D Vaidya, A Rodriguez - Fertility and sterility, 2009 - Elsevier Unfortunately, culture day 3 morphological assessment is not optimal for the prediction of blastocyst progression on culture day 5 (4) and (5). Investigators have therefore sought quantifiable objective measures of embryonic health with a focus on metabolic activity (6), (7), (8), (9), (10) and ...


ACAT1 deletion in murine macrophages associated with cytotoxicity and decreased expression of collagen type 3A1
A Rodriguez, MD Ashen… - Biochemical and biophysical …, 2005 - Elsevier In contrast to some published studies of murine macrophages, we previously showed that ACAT inhibitors appeared to be anti-atherogenic in primary human macrophages in that they decreased foam cell formation without inducing cytotoxicity. Herein, we examined foam cell formation ...


A synonymous variant in scavenger receptor, class B, type I gene is associated with lower SR-BI protein expression and function
…, JS Kieft, MZ Carletti, LK Christenson, A Rodriguez - Atherosclerosis, 2010 - Elsevier SR-BI RNA secondary structure, turnover, polysomal distribution and protein expression were examined in COS cells transfected with wild-type or rs5888-SR-BI plasmids by selective 2?-hydroxyl acylation and primer extension assays, actinomycin D inhibition, polysomal ...


Lipid-Lowering Medications in the Elderly
A Rodriguez - Clinical Geriatrics, 2005 - clinicalgeriatrics.com FULL DISCLOSURE POLICY AFFECTING CME ACTIVITIES As a provider accredited by the Accreditation Council for Continuing Medical Education (ACCME), it is the policy of Johns Hopkins University School of Medicine to require the disclosure of the existence of any significant ...


Expression of SR-BI and LDL receptor and differential use of lipoproteins to support early steroidogenesis in luteinizing macaque granulosa cells
M Puttabyatappa, E Greason, A Rodriguez… - Endocrinology, 2008 - Endocrine Soc ... Mary Cherian-Shaw2, Muraly Puttabyatappa2, Erin Greason3, Annabelle Rodriguez3, Catherine ... Velasco M, Alexander C, King J, Zhao Y, Garcia J, Rodriguez A 2006 Association of lower plasma estradiol levels and low expression of scavenger receptor class B, type I in ...


Abstract 1096: Predictors Of Carotid Intimal-medial Thickness In Subjects With Hyperalphalipoproteinemia
…, B Asztalos, T Pollin, W Post, A Rodriguez - Circulation, 2007 - Am Heart Assoc HDL cholesterol (HDL-C) is inversely associated with risk for CVD in the general population. However, the metabolic pathways leading to high HDL (hyperalphalipoproteinemia) are complex, and some patients with high HDL-C are not protected against atherosclerotic ...


Deficiency of Scavenger Receptor Class B Type I Negatively Affects Progesterone
J Wang, R Brogan, C Chaffin, A Rodriguez - 2010 - jhsph.edu ... Antonina Kolmakova, Jiangxia Wang, Rebecca Brogan, Charles Chaffin and Annabelle Rodriguez ... Negatively Affects Progesterone Secretion in Human Granulosa Cells Antonina Kolmakova, Jiangxia Wang, Rebecca Brogan, Charles Chaffin, and Annabelle Rodriguez ...


Association of Scavenger Receptor Class B Type I Polymorphisms With Subclinical Atherosclerosis
…, BA Wasserman, DM Herrington, A Rodriguez - 2010 - Am Heart Assoc .DC1.html http://circgenetics.ahajournals.org/content/suppl/2009/12/11/CIRCGENETICS.109.903195 Data Supplement (unedited) at: ... Association of Scavenger Receptor Class B Type I ... Adam C. Naj, PhD; Michael West, MD, PhD; Stephen S. Rich, PhD; Wendy Post, MD, MS; WH ...


An ex vivo Study of Foam Cell Formation and Cholesterol Clearance in Macrophages Isolated from Patients with Hypertriglyceridemia and Low High-Density
A Rodriguez… - Heart Drug, 2000 - content.karger.com High-density lipoproteins (HDL) are thought to be cardioprotective due to their role in decreasing cholesterol accumulation and in enhancing cholesterol removal from foam cells. Our study will examine foam cell formation and HDL-mediated cholesterol removal from macrophages ...


The impact of luteal phase support on gene expression of extracellular matrix protein and adhesion molecules in the human endometrium during the window of …
Y Zhao, J Garcia, L Kolp, C Cheadle, A Rodriguez… - Fertility and sterility, 2010 - Elsevier Endometrial biopsies were obtained on the day of oocyte retrieval (group I) and 3–5 days later (group II) after randomization into 3 groups. Group IIa had no luteal phase support, group IIb had luteal support with micronized progesterone, and group IIc had luteal support with ...


Deficiency of Scavenger Receptor Class B Type I Negatively Affects Progesterone Secretion in Human Granulosa Cells
…, J Wang, R Brogan, C Chaffin, A Rodriguez - Endocrinology, 2010 - Endocrine Soc Our goal was to examine the effect of deficiency of the lipoprotein receptor, scavenger receptor class B type I (SR-BI), on progesterone secretion in human granulosa cells (HGL5). Scrambled or SR-BI small interfering RNA [knockdown (KD)] cells were exposed to dimethylsulfoxide ...


Core Defects Of Type 2 Diabetes: Filling The Knowledge Gaps, Improving Practice
A Rodriguez - jhasim.com An estimated 2.2 million people in Mexico had type 2 diabetes in 2000, and the World Health Organization projects an increase to 6.13 million by 2030. 1 Because diabetes is the main cause of death in Mexican adults, 2 it is vital that practitioners diagnose diabetes early, and ...


Control of Lipids at Baseline in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Trial
R Pop-Busui, JS Rana, A Rodriguez… - Preventive …, 2009 - Wiley Online Library In order to examine lipids, a major treatment parameter in those with diabetes and heart disease, the authors analyzed baseline data from the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial. The study consisted of 2368 participants with ...


AUTHORS'RESPONSE TO LETTER FROM STRANDBERG AND COLLEAGUES
CGP Roberts, A Rodriguez - The Journals …, 2008 - biomedgerontology.oxfordjournals. … Drs. Strandberg, Pitkala, and Tilvis report unpublished follow-up results of the DEBATE [Drugs and Evidence Based Medicine in the Elderly] trial, which randomized 400 community-dwelling elderly adults with self-reported atherosclerotic disease to interventions according to ...


Diabetes Management: Complications Risk Assessment, Diagnosis, and Therapeutic Options
A Rodriguez - JAMA: The Journal of the American Medical …, 2002 - Am Med Assoc On numerous occasions I found myself cheering the efforts of Dr Charles in his quest to step beyond current conventions in the management of diabetes mellitus. In the preface, he states that he wishes to "bring a combination approach to treating the diabetic patient, focusing ...


Association of Scavenger Receptor Class B Type I Polymorphisms With Subclinical AtherosclerosisCLINICAL PERSPECTIVE
DM Herrington, A Rodriguez - Circulation: …, 2010 - Am Heart Assoc Methods and Results— Forty-three SCARB1-tagging SNPs were genotyped. Baseline examinations included fasting lipids and subclinical atherosclerosis phenotypes (coronary artery calcification, common carotid intimal-medial artery thickness [CCIMT], and internal carotid ...


Abstract 1389: The Association Of Scavenger Receptor Class B Type I (SR-BI) Protein With HDL-C Levels In Humans With Hyperalphalipoproteinemia
A Rodriguez, E Greason, CG Roberts, M West… - Circulation, 2007 - Am Heart Assoc In mice, deficiency of scavenger receptor class B type I (SR-BI) is associated with increased HDL-C levels. However, the relationship of SR-BI with HDL-C levels in humans is still unclear. Therefore, community-dwelling adult subjects between the ages of 18 – 80 years ...


Endoscopic Localization and Tattooing of a Proinsulinoma for Minimally Invasive Resection
A Rodriguez, MI Canto… - Pancreas, 2011 - journals.lww.com Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. ... Skip Navigation Links Home > Current ...


Problemas Principales En El Tratamiento De La Diabetes Tipo 2: Llenar Los Vacíos Del Conocimiento, Mejorar La Práctica
A Rodriguez - jhasim.com Se calcula que en México, en el año 2000, hubo 2,2 millones de personas con diabetes tipo 2, y la Organización Mundial de la Salud proyecta que la cifra aumentará a 6,13 millones en 2030. 1 Debido a que la diabetes es la causa principal de muerte en los mexicanos ...


PRINCIPAIS DEFICIÊNCIAS DO DIABETES TIPO 2: PREENCHENDO LACUNAS DO CONHECIMENTO E MELHORANDO A PRÁTICA
A Rodriguez - jhasim.com De acordo com estimativas de prevalência da Organização Mundial da Saúde, aproximadamente 4,6 milhões de pessoas no Brasil tinham diabetes tipo 2 em 2000, ea previsão é que em 2030 esse número tenha no mínimo duplicado. 1 Embora as taxas de prevalência do diabetes ...


Dr. Annabelle Rodriguez, M.D.

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